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KMID : 1007020070050020085
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Korean Soceity of Osteroporosis
2007 Volume.5 No. 2 p.85 ~ p.93
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The Effects of Hormone Therapy and Raloxifen on the Bone Mineral Densities and Bone Metabolism of Postmenopausal Women
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Kim Nam-Su
Kim Heung-Yeol
Lee Tae-Hwa
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Abstract
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Objectives: To evaluate the effects of hormone therapy and Raloxifen on the bone mineral density and bone metabolism in the postmenopausal women.
Methods: This prospective randomized clinical trial examined the effects of Raloxifene and conjugated equine estrogen, on bone mineral density (BMD) and biochemical markers of bone turnover in 149 women with low bone mass. Treatment included Raloxifen (group I, n=63), or conjugated equine estrogen (group II, n=86), for 12 months. Bone density measurements were performed at months 6 and 12 months at the lumbar spine and femur neck. Biochemical markers of bone turnover were also measured every six months.
Results: BMD of lumbar spine, it increased significantly during the treatment in Group I, Group II (P<0.005). As for BMD of femur neck, it increased slightly during the treatment in Group I and Group II, but not significantly. Serum osteocalcin and urinary deoxypyridinoline in Group I and Group II decreased significantly at 12 months of treatment (P<0.005).
Conclusion: The treatment with Raloxifen and conjugated equine estrogen is effective in postmenopausal women with osteoporosis by decreasing bone biochemical markers and by increasing the BMD.
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KEYWORD
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Raloxifen, Bone biochemical markers, Bone mineral density, Osteoprorosis
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